Zhang Ruxu

Associate Professor of Neurology

Education

Psotdoc.(2008-2009)  the Dept. of Neurology, University Clinic Bonn, Germany

Ph.D. (2000-2005)   Xiangya Medical College, Central South University, China

M.D. (1992-1997)   Xiangya Medical University, China.

Work Experience

Department of Neurology, the Third Xiangya Hospital, Central South University, Hunan, P.R. China

2012- now               Vice director and associate Professor

2011-2012               Associate Professor

2004-2011               Chief Attending

1997-2004               Resident and Chief Resident

Committee and Broad Memberships

1. Standing member, Neural genetics branch of China neurologist association

2. Standing member, Neurology committee of Hunan province

3. Standing member, Group of Neuro-Immunology and Neuromuscular Medicine, Neurology committee of hunan province

4. Standing member, Chinese Association of Integrative Medicine Neuroscience Professional Committee.

5. Member, Chinese Neuroscience Society

6. Member, Chinese Medical Association

Clinical and Research Interests

1.Neuromuscular Medicine.

2. Genetic diagnosis, gene cloning, pathogenic study, genetic counseling of neurodegenerative Diseases, especially Charcot-Marie-Tooth disease (CMT).

3.Resident training and medical education.

Foreign Language

English, Good command of both spoken and written English.

German, Basic command of German.

Teaching Courses

1. Neurology

2. Family medicine

3. Clinical communication skills

Contact Me

Address: Tongzipo Road 138#, Changsha, Hunan，P.R. China 410013

Tel: +86-731-8618007(O); Fax: +86-731-8618007

Email: zhangruxu@vip.163.com

Research Projects

01/2013-12/2015   Principal investigator: The clinical use of diagnostic gene chip of CMT (Proj.No. 13JJ2014)

01/2011-12/2013    Principal investigator: the pathogenesis study of CMT by using CMT2L transgenic mouse model. National Natural Science Foundation of China (Proj.No. 81071001)

01/2014-12/2016    Principal investigator: The clinical research of CMT (125 project of Hunan province)

07/2006-07/2007   Principal investigator: the pathogenesis study of HSP22 and HSP27 in Charcot-Marie-Tooth disease. National Natural Science Foundation of China (Proj.No. 30600200)

07/2006-07/2008    Principal investigator: The pathogenesis study of small heat shock protein 22 in Charcot-Marie-Tooth disease. Hunan provincial Nature Science Foundation of China (Proj.No. 06jj30009)

07/2006-07/2007    Principal investigator: The RNAi therapy study in Charcot-Marie-Tooth disease type 1A. Grant from the Health Board of Hunan province of China (Proj.No. B2006088) 01/2007-12/2010 )

Selected Recent Publications

1. Li X, Hu Z, Tang B, Zhang R*. A SIGMAR1 splice-site mutation causes distal hereditary motor neuropathy. Neurology. 2015;84(24):2430-2437. (Corresponding author)

2. Zhan Y, Zi X, Tang B, Zhang R*. PMP22 related neuropathies and other clinical manifestations in Chinese Han patients with CMT1. Muscle Nerve. 2015;52(1):69-75. (Corresponding author)

3. Y. Z. Xie, R. X. Zhang R*. Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery. Neurol Sci (2015) 36:21-27. (Corresponding author)

4. Lei Liu, Ruxu Zhang*. Intermediate Charcot-Marie-Tooth disease. Neurosci Bull, 2014, 30(6): 999–1009. (Corresponding author)

5. Lei Liu, Xiaobo Li, Beisha Tang, Ruxu Zhang*, et al. Two novel MPZ mutations in Chinese CMT patients. J Peripher Nerv Syst. 2013;18(3):256-260. (Corresponding author)

6. Ruxu Zhang, Fufeng Zhang, Xiaobo Li, et al. A novel transgenic mouse model of Chinese Charcot- Marie-Tooth disease type 2L. Neural Regeneration Research.2014,6(8):706-711. (Corresponding author)

7. Xiaobo Li, Xiaohong Zi, Ruxu Zhang*, et al. Rapid genetic screening of Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies patients. Neural Regen Res. 2012,7（32）：2522-2527. (Corresponding author)

8. Ruxu Zhang, Xiaobo Li, Xiaohong Zi, et al. Clinical Classification and Gene Mutation of chinese Charcot-Marie-Tooth Disease：Analysis of 57 cases. Neural Regeneration Research.2011,6(9):706-711. (Corresponding author)

Selected Recent Oral Presentations

1. The genetic analysis and phenotype study of 247 Chinese IPN pedigrees. 18th National Conference of Neurology 2015, Chengdu, China.

2. Gene cloning of a consanguineous dHMN family and the functional study. The 8th national young neurologist conference 2015 Chongqin, China.

3. PMP22 related neuropathies and other clinical manifestations in Chinese Han patients with CMT1. 17th National Conference of Neurology 2015, Xiamen, China.

4. Intermediate Charcot-Marie-Tooth disease. 17th National Conference of Neurology 2015, Xiamen, China.

5. A novel transgenic mouse model of Chinese Charcot- Marie-Tooth disease type 2L. 7th National Congress of Chinese Neuroscience Academy 2012, Zhenzhou. China.